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Awake & Asleep Fluoride-Free Nano-Hydroxyapatite Toothpaste, Day & Night System

Awake & Asleep Fluoride-Free Nano-Hydroxyapatite Toothpaste, Day & Night System

Your mouth doesn’t stay the same from morning to night. Two toothpastes, one system. Formulated around your mouth’s biology, not against it. Awake for the morning, Asleep for the night. 12+ active ingredients for stronger teeth, calmer gums and fresher breath. You don’t rinse them off, so they keep working — even while you sleep.

Used and recommended by 100+ kPNI practitioners
Clinically proven ingredients · 36 peer-reviewed studies
Leave-on, no rinse
Nano-hydroxyapatite, fluoride-free
Recommended by functional dentists
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  Pay every 12 months, Deliver every 6 months_
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 ships every 60 days
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 ships every 60 days
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each
 6 duos a year (3 now, 3 in month 6)
€67
€67
each
 6 duos a year (3 now, 3 in month 6)
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Regular price €67,00 EUR
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What you'll feel (and your dentist notices)
First 60 days
  • First brush

    — a smoother clean, an extra layer you can feel

  • First night

    — feel the repair, it keeps working while you sleep

  • Week 1

    — sensitivity starts to fade, the mineral layer builds

  • Week 2

    — calmer gums, fresher breath, morning and night

  • Week 4

    — less plaque, mouth bacteria back in balance (oral microbiome)

  • Week 6

    — weak spots remineralised, enamel stronger

  • By day 60

    — smoother, brighter, calmer care that strengthens more than your teeth

The Karmicare effect
Beyond 60 days
  • Awake protects the day, Asleep restores the night*

    — you start needing both

  • Calmer check-ups*

    — arrive resilient, you did the work at home

  • Evenings that wind down*

    — no sting, nothing to rinse

  • You smile more*

    — and think about it less

  • Peace of mouth, peace of mind*

    — from your gums to the rest of you

  • Awake protects the day, Asleep restores the night*

    — you start needing both

* What members report with continued use — individual experiences vary.

Why Karmicare

Karmicare cares for both your mouth and your state of mind through two distinct brushing experiences. One that helps you begin the day, and one that helps you let it go

Ingredients
Actives Awake
  • Guarana
  • Peppermint + Lime
  • Bentonite clay
Actives Asleep
  • Valerian
  • Orange + Cinnamon
  • Activated charcoal
Foundation of both formulas
  • Nano-hydroxyapatite (nHAp), the mineral your teeth are made of
  • Xylitol, balances the oral microbiome
  • Glycolipids, fermented sugar
Full ingredient list (INCI)
Awake Morning Toothpaste (2.0) Aqua, Glycerin, Xylitol, Sorbitol, Calcium Carbonate, Hydroxyapatite [Nano], Hydrated Silica, Bentonite, Perlite, Glycolipids, Potassium Chloride, Cocos Nucifera Water, Xanthan Gum, Mentha Piperita Oil, Citrus Aurantifolia Oil, Triethyl Citrate, Leuconostoc/Radish Root Ferment Filtrate, P-Anisic Acid, Paullinia Cupana Seed Extract, Menthol, Limonene, Pinene, Terpineol, Terpinolene, Beta-Caryophyllene, Alpha-Terpinene, Carvone, Linalool, Citral, Geraniol, Camphor, Eugenol.
Asleep Evening Toothpaste (2.0) Aqua, Glycerin, Xylitol, Sorbitol, Calcium Carbonate, Hydroxyapatite [Nano], Hydrated Silica, Bentonite, Perlite, Glycolipids, Potassium Chloride, Cocos Nucifera Water, Xanthan Gum, Citrus Sinensis Peel Oil Expressed, Charcoal Powder, Cinnamomum Cassia Bark Extract, Triethyl Citrate, Valeriana Officinalis Rhizome/Root Extract, Maltodextrin, Leuconostoc/Radish Root Ferment Filtrate, P-Anisic Acid, Silica, Citrus Aurantium Peel Oil, Limonene, Cinnamomum Cassia Leaf/Bark Oil, Cinnamal, Cinnamyl Alcohol, Coumarin, Linalool, Beta-Caryophyllene, Citral, Citronellol, Pinene, Geraniol.
What's not in it
Fluoride-free SLS & sulfate-free Sodium benzoate-free Triclosan-free Paraben-free Microplastic-free Alcohol-free PEG-free Saccharin-free Vegan · animal-free No artificial colours
How to use
Rinse first
Clean start
One pump
Full dose
Spit, no rinse
Let it work

One precise, hygienic pump. Brush gently for 1–2 minutes. Spit, don’t rinse.

Run your tongue over your teeth: that smooth edge is the clean

Rinsing ends it the moment it starts; the minerals leave with the water. Left on, the contact carries on long after the brush. The same principle dental clinics use in-office, adapted for a daily ritual at home. Safe for children. Safe when swallowed.

Taste & feel

Before you start. 

Run your tongue over your teeth: a faint fuzz in the morning, the day’s coffee and talking in the evening. Don’t judge it — that’s your before.

Awake: bright peppermint and lime, guarana underneath — a velvety foam, made with fermentation-derived glycolipids, so nothing stings and nothing goes dry. Spit, don’t rinse. Tongue again: the fuzz is gone, every tooth a smooth, glassy edge.

Asleep: warm orange and cassia cinnamon, valerian in the background, intentionally mint-free. Spit and leave it. 
Tongue over teeth: smooth, and a fine, even coat — as if the day had been closed.

The first week: the velvety foam and the leave-on feel are what people notice first. By the fifth brush it’s the smoothness. Two seconds, twice a day, and you know.

Quality & safety
Safety-assessed for leave-on use
Independent EU-qualified assessor · Reg. 1223/2009 Annex I
CPSR · 2026
VIEW ASSESSMENT SUMMARY
Notified on the EU cosmetic products portal
CPNP · Responsible Person KARMICA BV, Bruges
CPNP · 2026
VIEW NOTIFICATION
nHAp within the EU SCCS-assessed specification
Rod-shaped, uncoated · Annex III entry 372
SCCS/1677/25
READ THE OPINION
Abrasivity measured, not asserted
Midwest University · RDA 93 Awake, 72 Asleep · ISO 11609 limit 250
Report 25-RDA-123 · Dec 2025
VIEW REPORT
Formulated on 36 peer-reviewed studies
Every ingredient has a published reason · evidence library with DOIs
Evidence library · 2026
READ OUR SCIENCE
See every document →
For dentists
FormulaRDASafety · ISO 11609
Awake · AM93.25✓ 63% below limit
Asleep · PM72.32✓ 71% below limit
ISO 11609 limit250Maximum allowed
i
Activated charcoal, in Asleep only. Pharmaceutical grade (Ph. Eur. “Charcoal, Activated”), steam-activated from a 100% natural, renewable raw material. Particle size D50 20 µm (D10 4 · D90 60 µm), BET surface ≈ 1,700 m²/g. It is in the formula for adsorption, not abrasion: at RDA 72, Asleep is the gentler of the two — this is not a charcoal-whitening paste.
nHAp <100 nm · rod-shaped, per SCCS Low–medium abrasivity Fluoride-free Mineral whitening Leave-on safe Safe to swallow EU CPNP-notified

Request the evidence pack, patient-ready materials, professional samples and technical documentation →

For kPNI / Orthomolecular practitioners

The missing oral-care piece in your protocols — biorhythmic, fluoride-free and connected through the oral–gut–brain axis.

Hormone-aware. Formulated without fluoride and without known endocrine-active ingredients, for practitioners who run thyroid- and pineal-aware protocols. The pineal–melatonin and fluoride–sleep literature is in the evidence pack.

Built on the body’s rhythm. Awake for the cortisol morning, Asleep for the repair night — supporting the natural recovery process instead of interrupting it.

Oral–gut–brain axis. What settles in the mouth is swallowed all night; the oral microbiome sits upstream of the gut and its signalling. Five studies in the pack.

Practitioner evidence pack and samples available →

Request the practitioner pack

Tell us about your practice and what you need. The evidence pack holds the studies referenced above. A person reads every request and replies by email.

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OUR MISSION

Strengthen your teeth. Strengthen yourself.

I built Karmicare from my own reset — when caring for my mouth became caring for my whole self.

— Victor, founder

View full details

CHRONOBIOLOGY

Your mouth runs on a 24-hour clock.

Bacteria, saliva and acids each keep their own hours. 

What it needs at 07:00 is not what it needs at 22:00.

≈ 06:40 · Neisseria peaks

Your mouth wakes up

Cortisol rises; coffee, breakfast and the day's first acids follow. Enamel needs its shield on first.

≈ 22:00 · Fusobacterium peaks

Your mouth switches to repair

Melatonin rises and saliva slows to a trickle. What's on your enamel at 22:00 is still there at 07:00.

· your mouth right now:

Drag the knob around the ring to preview a local time. Release to return to the current time. Hold an arrow key to preview in five-minute steps; Page Up and Page Down change one hour. Home selects midnight; End selects 23:59. Release the key, press Escape, or leave the control to return to now.

PROFESSIONAL PARTNERS

Trusted by professionals who look beyond the teeth

  • “I have been using Karmicare for a long time and feel strongly drawn to their vision of oral care. Our mouth, too, follows the natural rhythm of our body: the oral environment is different during the day than at night. What’s more, oral health does not stand on its own; it is closely connected to our general health.

    As a dentist, I find the formulation interesting because of the combination of, among other things, nano-hydroxyapatite and xylitol in a fluoride-free leave-on formula. Because you don’t need to rinse after brushing, the caring ingredients stay in contact with the teeth and the mouth for longer. The two different formulas also fit nicely within the vision of our natural day-and-night rhythm: fresh and invigorating in the morning (with guarana for morning energy), and warmer and spicier in the evening (with valerian, which contributes to calm and relaxation).

    My patients who use Karmicare are very happy with it and find it a pleasant toothpaste. My children, who are critical about flavours, also use Karmicare with pleasure! I find that at least as important: good oral care starts with a toothpaste you enjoy and keep using consistently. Wonderfully fresh, without feeling aggressive in the mouth. I’m a fan!”

    Dr. Stephanie Spreuwers

    Functional Dentist, kPNI Practitioner

  • “As a dental hygienist and quality manager with more than 13 years of experience in oral healthcare, I am critical about which products I recommend. What I particularly value about Karmicare is the combination of an effective and safe formulation that is also pleasant to use.

    In my own experience I notice a pleasant taste, a smoother feel on the teeth and teeth that look whiter, and all that without fluoride. It offers an interesting and reliable alternative for both professional and everyday use.

    I see Karmicare as a valuable addition to modern oral care and see good potential for use by a broad audience.”

    Mariama Banjai

    Dental Hygienist, Oral Care Quality Manager

  • “Karmicare offers fluoride-free oral care in a thoughtful way, with hydroxyapatite as a scientifically supported choice. By also taking biorhythm into account, the brand touches on the foundations on which true health is built. This vision aligns seamlessly with my professional conviction that only an integrated approach, bringing together science, biology, rhythm and nature, leads to lasting health.”

    Leen Ponet

    Pharmacist, Orthomolecular Practitioner, kPNI Coordinator

  • Dr. Iveta Pleša Rutule

    Holistic Dentist

  • Dr. Kris Sienaert

    Former GP, Lifestyle Medicine

  • “As a nutritional therapist specialized in female hormones, I’m extremely careful about what I put into my body. Hormones are sensitive. Stress, toxins, poor-quality ingredients — they all add up. So I don’t just look at labels, I look at what something will do inside the body.

    I choose Karmicare because I trust what’s in it — and what’s not. No unnecessary fillers, no hidden disruptors. Just clean, purposeful ingredients that support rather than burden the nervous system and hormonal balance. When you understand how delicate the female endocrine system can be, especially under chronic stress, quality isn’t optional.

    And that’s also why I use it in my practice.

    I work with women dealing with PMS, cycle issues, stress-related fatigue, estrogen dominance and adrenal dysregulation. I need products that are technically sound — bioavailable, well-formulated, and supportive of detox pathways and nervous system regulation.

    Karmicare fits that standard.”

    Sietske Hamelink

    Nutritional Practitioner, Menstrual Cycle Expert

  • Kim Verlot

    Breathing Coach, Heart Coherence Specialist

CARE THAT COMPOUNDS

Everything else in your routine maintains. This one strengthens your teeth, and yourself.

Awake protects the day. Asleep restores the night. Care timed to your biology — still working long after you've put it down.
Compare
Regular brushing
Daily supplements
Skincare routine
It’s timed to your biology
Your mouth’s own 24-hour cycle
Same formula, any hour
One dose fits all
AM/PM by convention
You feel it straight away
Guarana by day, valerian by night
Mint, then nothing
Weeks to notice
Nothing to feel
It reaches past your teeth
Oral-gut-brain, deeper than enamel
Mechanical cleaning only
Systemic, not oral
Stops at the skin
It keeps working after you stop
Leave-on. No rinse. Extended contact time.
Rinsed away in seconds
Nothing local
Skin only
It feeds, not just cleans
One pump, minerals and balance
Squeeze, guess, rinse away
Nothing reaches enamel
Surface renewal only
The person it makes you
Someone who tends to themselves
Someone who ticks a box
Someone who means to
Someone who tends the surface
CLINICALLY BACKED ORAL CARE

The research behind the system

Return on Care

Care that comes back.

Karmicare is a care system: the ritual arrives on your rhythm, and your care builds Care Credit as you go.

  1. Your ritual

    Two minutes, morning and night. Your membership returns Care Credit: 10% of every 60-Day Rhythm, 20% of the Year.

  2. Your check-up

    On the Year, a check-up after month six adds €40 in Care Credit, once per membership year. You walk in with something to gain, not only something to pay.

  3. Your next order

    Spend Care Credit on any order. It stays valid while you are a member, and for 12 months after.

Your first Year in Care Credit

Received

Return on Care20% back on the Year
€70.80
Dental Check-up Rewardafter month six
€40.00
Up to
€110.80

Care Credit is Karmicare credit: spend it on more care. It rewards the visit, not the verdict. Not insurance, and not a payment towards treatment.

Terms, clauses 10 and 11
choose your rhythm

One system. 
Three ways to begin.

Start with one set, refill every 60 days, or choose the full year — the ritual stays the same: Awake in the morning, Asleep at night.

Compare
Duos in a year
Cost per brushing
Delivery rhythm
Return on Care

Return on Care is our give-back: a share of every delivery comes back to you as Care Credit — in euros, spendable on member products and accessories. We believe prevention should pay the person doing the caring.

Care Credit earned in a year

Care Credit is what Return on Care pays out — in euros, spendable on member products and accessories. We believe prevention should pay the person doing the caring.

Welcome Kit Welcome Kit· €21 Value · Free Morning Toothbrush Morning Toothbrush Free · €6 Evening Toothbrush Evening Toothbrush Free · €6 Whitening Charcoal Floss Whitening Charcoal Floss Free · €9
€40 Check-up Reward

Complete a dental check-up from month 6 or onwards. €40 in Care Credit is added to your account. Prevention, rewarded.

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Try Once€67 one-time
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Brushing & Beyond
The Karmicare Year€354 /year
6
€0.49
2× a year

Two shipments a year — the first at signup, the second around month 6. Each is a six-month supply of Awake and Asleep, so you're always stocked.

20% back
€70.80
✓
✓
✓
Free
60 days

Every subscription earns Care Credit: a return on the care you keep.